Genesis 4:17

Cain knew his wife. She conceived, and gave birth to Enoch. He built a city, and called the name of the city, after the name of his son, Enoch.

World English Bible
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Other translations

WEBBE

Cain knew his wife. She conceived, and gave birth to Enoch. He built a city, and named the city after the name of his son, Enoch.

BSB

And Cain had relations with his wife, and she conceived and gave birth to Enoch. Then Cain built a city and named it after his son Enoch.

KJV

And Cain knew his wife; and she conceived, and bare Enoch: and he builded a city, and called the name of the city, after the name of his son, Enoch.

ASV

And Cain knew his wife; and she conceived, and bare Enoch: and he builded a city, and called the name of the city, after the name of his son, Enoch.

BBE

And Cain had connection with his wife and she became with child and gave birth to Enoch: and he made a town, and gave the town the name of Enoch after his son.

Original Hebrew

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The early church

Consider now the text: "And Cain knew his wife, and she conceived, and brought forth Enoch; and he built a city and called the name thereof by the name of his son Enoch." It does not at all follow from these words that we must believe Cain's first son was Enoch, as though "Cain knew his wife" must refer to their first intercourse. You have the same expression used of the first father, Adam, but not only in reference to the conception of Cain, who seems to have been his firstborn, since a little later Scripture records, "Adam knew his wife, and she conceived and brought forth a son and called his name Seth."
Augustine of Hippo · d. 430City of God
Now, it is recorded of Cain that he built a city, while Abel, as though he were merely a pilgrim on earth, built none. For the true city of the saints is in heaven, though here on earth it produces citizens in whom it wanders as on a pilgrimage through time looking for the kingdom of eternity. When that day comes, it will gather together all those who, rising in their bodies, shall have that kingdom given to them in which, along with their Prince, the King of Eternity, they shall reign forever and ever.
Augustine of Hippo · d. 430City of God

Commentary

Matthew Henry · Verses 16–18

Cain cast off all fear of God, and attended no more on God's ordinances. Hypocritical professors, who dissemble and trifle with God, are justly left to themselves to do something grossly scandalous. So they throw off that form of godliness to which they have been a reproach, and of which they deny the power. Cain went out from the presence of the Lord, and we never find that he came into it again, to his comfort. The land Cain dwelt in was called the land of Nod, which means, shaking,' or trembling,' and so shows the restlessness and uneasiness of his own spirit, or the land of a vagabond:' they that depart from God cannot find rest any where else. Those on earth who looked for the heavenly city, chose to dwell in tabernacles or tents; but Cain, as not minding that city, built one on earth. Thus all who are cursed of God seek their settlement and satisfaction here below.

Read Matthew Henry on Genesis 4 →

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Cross-references: Treasury of Scripture Knowledge. Hebrew and Greek data from STEPBible.org (Tyndale House, Cambridge), CC BY 4.0. Library: sources.