Matthew 16:21

From that time, Jesus began to show his disciples that he must go to Jerusalem and suffer many things from the elders, chief priests, and scribes, and be killed, and the third day be raised up.

World English Bible
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WEBBE

From that time, Jesus began to show his disciples that he must go to Jerusalem and suffer many things from the elders, chief priests, and scribes, and be killed, and the third day be raised up.

BSB

From that time on Jesus began to show His disciples that He must go to Jerusalem and suffer many things at the hands of the elders, chief priests, and scribes, and that He must be killed and on the third day be raised to life.

KJV

From that time forth began Jesus to shew unto his disciples, how that he must go unto Jerusalem, and suffer many things of the elders and chief priests and scribes, and be killed, and be raised again the third day.

ASV

From that time began Jesus to show unto his disciples, that he must go unto Jerusalem, and suffer many things of the elders and chief priests and scribes, and be killed, and the third day be raised up.

BBE

From that time Jesus went on to make clear to his disciples how he would have to go up to Jerusalem, and undergo much at the hands of those in authority and the chief priests and scribes, and be put to death, and the third day come again from the dead.

Original Greek

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The early church

And observe that it is not said,' He began to say,' or 'to teach,' but to show; for as things are said to be shown to the sense, so the things which Christ spake are said to be shown by Him. Nor indeed do I think, that to those who saw Him suffering many things in the flesh, were those things which they saw so shown as this representation in words showed to the disciples the mystery of the passion and resurrection of Christ. At that time, indeed, He only began to show them, and afterwards when they were more able to receive it, He showed them more fully; for all that Jesus began to do, that He accomplished. He must needs go to Jerusalem, to be put to death indeed in the Jerusalem which is below, but to rise again and reign in the heavenly Jerusalem. But when Christ rose again, and others were risen with Him, they no longer sought the Jerusalem which is beneath, or the house of prayer in it, but that which is above. He suffers many things from the elders of the earthly Jerusalem, that He may be glorified by those heavenly elders who receive His mercies. He rose again from the dead on the third day, that He may deliver from the evil one, and purchase for such as are so delivered this gift, that they be baptized in spirit, soul, and body, in the name of the Father, and the Son, and the Holy Spirit, who are three days perpetually present to those that through them have been made children of light.
Origen of Alexandria · d. 253Catena Aurea (Aquinas, 1274)
"From that time forth began He to show unto them that He must suffer. From that time." What time? When He had fixed the doctrine in them; when He had brought in the beginning of the Gentiles. But not even so did they understand what He said. "For the saying," it is said, "was hid from them;" and they were as in a kind of perplexity, not knowing that He must rise again. Therefore He rather dwells on the difficulties, and enlarges His discourse, that He may open their mind, and they may understand what it can be that He speaks of. "But they understood not, but the saying was hid from them, and they feared to ask this;" not whether He should die, but how, and in what manner, and what this mystery could be. For they did not even know what was this same rising again, and supposed it much better not to die.
John Chrysostom · d. 407Homilies on Matthew
For what having once had root has afterwards been torn up, if it is again planted, is with difficulty retained among the multitude; but what having been once rooted has continued ever after unmoved, is easily brought on to a further growth. He therefore dwells on these sorrowful things, and repeats His discourse upon them, that He may open the minds of His disciples.
John Chrysostom · d. 407Catena Aurea (Aquinas, 1274)
When then above He sends His disciples to preach, and commands them to proclaim His advent, this seems contrary to His command here, that they should not say that He is Jesus the Christ. To me it seems that it is one thing to preach Christ, and another to preach Jesus the Christ. Christ is a common title of dignity, Jesus the proper name of the Saviour. But that none should suppose that this is only my explanation, and not an evangelic interpretation, what follows explains the reasons of His forbidding them to preach Him at that time; Then began Jesus to show unto his disciples that he must needs go unto Jerusalem, and suffer many things of the elders and Scribes, and Chief Priests, and be put to death, and rise again the third day. The meaning is; Then preach Me when I shall have suffered these things, for it will be of no avail that Christ be preached publicly, and His Majesty spread abroad among the people, when after a little time they shall see Him scourged and crucified.
Jerome · d. 420Catena Aurea (Aquinas, 1274)

Commentary

Matthew Henry · Verses 21–23

Christ reveals his mind to his people gradually. From that time, when the apostles had made the full confession of Christ, that he was the Son of God, he began to show them of his sufferings. He spake this to set right the mistakes of his disciples about the outward pomp and power of his kingdom. Those that follow Christ, must not expect great or high things in this world. Peter would have Christ to dread suffering as much as he did; but we mistake, if we measure Christ's love and patience by our own. We do not read of any thing said or done by any of his disciples, at any time, that Christ resented so much as this. Whoever takes us from that which is good, and would make us fear to do too much for God, speaks Satan's language. Whatever appears to be a temptation to sin, must be resisted with abhorrence, and not be parleyed with. Those that decline suffering for Christ, savour more of the things of man than of the things of God.

Read Matthew Henry on Matthew 16 →

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Cross-references: Treasury of Scripture Knowledge. Hebrew and Greek data from STEPBible.org (Tyndale House, Cambridge), CC BY 4.0. Library: sources.