Matthew 27:34

Or, He therefore refused the wine mingled with gall, because the bitterness of sin is not mingled with the incorruption of eternal glory.

And they gave Him gall to drink, and this to insult Him, but He would not. But another saith, that having tasted it, He said, "It is finished." And what meaneth, "It is finished?" The prophecy was fulfilled concerning Him. "For they gave me," it is said, "gall for my meat, and for my thirst they gave me vinegar to drink." But neither doth that evangelist indicate that He drank, for merely to taste differs not from not drinking, but hath one and the same signification.

The bitter vine makes bitter wine; this they gave the Lord Jesus to drink, that that might be fulfilled which was written, They gave me also gall for my meat. (Ps. 69:21.) And God addresses Jerusalem, I had planted there a true vine, how art thou turned into the bitterness of a strange vine? (Jer. 2:21.)

And they gave him to drink wine mingled with gall. Mark says, mingled with myrrh. Matthew put gall (Mark 15:23.) to express bitterness, but wine mingled with myrrh is very bitter; though indeed it might be, that gall together with myrrh would make the most bitter. And when he had tasted thereof, he would not drink. That Mark says, But he received it not, we understand to mean that He would not receive it to drink thereof. For that He tasted it Matthew bears witness; so that Matthew's, He could not drink thereof, means exactly the same as Mark's, He received it not; only Mark does not mention His tasting it. That He tasted but would not drink of it, signifies that He tasted the bitterness of death for us, but rose again the third day.