Psalms 38:3

Nothing will disquiet the heart of a good man so much as the sense of God's anger. The way to keep the heart quiet, is to keep ourselves in the love of God. But a sense of guilt is too heavy to bear; and would sink men into despair and ruin, unless removed by the pardoning mercy of God. If there were not sin in our souls, there would be no pain in our bones, no illness in our bodies. The guilt of sin is a burden to the whole creation, which groans under it. It will be a burden to the sinners themselves, when they are heavy-laden under it, or a burden of ruin, when it sinks them to hell. When we perceive our true condition, the Good Physician will be valued, sought, and obeyed. Yet many let their wounds rankle, because they delay to go to their merciful Friend. When, at any time, we are distempered in our bodies, we ought to remember how God has been dishonoured in and by our bodies. The groanings which cannot be uttered, are not hid from Him that searches the heart, and knows the mind of the Spirit. David, in his troubles, was a type of Christ in his agonies, of Christ on his cross, suffering and deserted.

There is no soundness in my flesh because of thine anger. Mental depression tells upon the bodily frame; it is enough to create and foster every disease, and is in itself the most painful of all diseases. Soul sickness tells upon the entire frame; it weakens the body, and then bodily weakness reacts upon the mind. One drop of divine anger sets the whole of our blood boiling with misery. Neither is there any rest in my bones because of my sin. Deeper still the malady penetrates, till the bones, the more solid parts of the system, are affected. No soundness and no rest are two sad deficiencies; yet these are both consciously gone from every awakened conscience until Jesus gives relief. God's anger is a fire that dries up the very marrow; it searches the secret parts of the belly. A man who has pain in his bones tosses to and fro in search of rest, but he finds none; he becomes worn out with agony, and in so many cases a sense of sin creates in the conscience a horrible unrest which cannot be exceeded in anguish except by hell itself.